The failure was a big blow to him, but he wasn't discouraged and soon got as enthusiastic as ever.

这次失败对他是一个巨大的打击，但他没有气馁，很快又恢复了热情。

youdao

The news came as a big blow.

那消息犹如晴天霹雳。

《牛津词典》

It was a big blow to his family.

这对他的家庭是个沉重的打击。

youdao

The injury is a big blow for the team with the worst record in the majors.

WSJ: Marlins beat Mets 4-3 in 15 innings

It is also a big blow for British hopes of staging the 2012 Olympics.

BBC: You are in: You are in: Athletics

Ibiden's success has been a big blow to Kyocera, but the contest is just beginning.

FORBES: It's all in the packaging